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Description
AME Guidance for Processing a Thrombocytopenia CACI (Condition AME Can Issue)
A a s i boilerplate

Conditions AMEs Can Issue (CACI) are a series of conditions which allow AMEs to regular issue the pilot medical certificate if the applicant meets the parameters of the CACI Condition Worksheet. The worksheets provide detailed instructions to the examiner and outline condition-specific requirements for the applicant.

  • AME must review the disposition table BEFORE the CACI worksheet to verify a CACI is required.
  • If all the CACI criteria are met and the applicant is otherwise qualified, the AME may issue on the first exam or the first time the condition is reported to the AME without contacting AMCD/RFS. Document the appropriate notes in Block 60 and keep the supporting documents in your files; they do not need to be submitted to the FAA at this time.
  • If the requirements are not met, the AME must defer the exam and send the supporting documents to the FAA.
Grid
DISEASE/CONDITION EVALUATION DATA DISPOSITION
A. 5 or more years ago
Most recent event/diagnosis 		No symptoms or current problems. No ongoing treatment OR surveillance needed. ISSUE
Summarize this history in Block 60.
B. Less than 5 years ago
Due to:
Drugs (including HIT*),
Infection (now resolved),
Pregnancy, etc.

*Heparin induced thrombocytopenia
  • Treating physician report verifies condition has resolved or, if due to a medication, it has been stopped with no plan to re-start.
  • No symptoms or current problems.
  • No ongoing treatment OR surveillance needed.

Note: If an underlying condition is identified, see that section. Example: Thrombocytopenia due to chemotherapy, malignancy, autoimmune disorders, or alcohol use. 		ISSUE
Summarize this history in Block 60
C. Less than 5 years ago
Immune thrombocytopenia (ITP) 		See CACI worksheet

Note: CACI is for Chronic ITP only. All other causes of thrombocytopenia, See item "D. All Others" below. 		Follow the CACI – Chronic Immune Thrombocytopenia (cITP) Worksheet

Annotate Block 60.
D. All others Submit the following to the FAA for review:
  • Current status report from the treating Hematologist with diagnosis, treatment plan and prognosis;
  • If an underlying cause is identified, the status report should include diagnosis, treatment plan, prognosis, and adherence to treatment for this condition;
  • List of medications and side effects, if any;
  • Operative notes and discharge summary (if applicable);
  • Copies of imaging reports or other lab (if already performed by treating hematologist); and
  • CBC within the past 90 days.
 DEFER
Submit the information to the FAA for a possible Special Issuance.

Follow up Issuance will be per the airman's authorization letter.
Sources:
FAA AME Guide Dec 2025 version
Fp post date
Sep 25, 2019
Created at
Dec 29, 2025
Updated at
Dec 29, 2025