Narcan Administration (Opiate Antagonist)

Page Contents
Description
FAA Aeromedical Views on Naloxone (Narcan) and Opioid Antidote
FlightPhysical.com Abbreviated Briefing

If you receive Narcan, don't fly until cleared by the FAA, No FAA Entries in the Green Column as of Jan 2026. No Safe Opioid Antidotes have been identified (your situation will be judged on a case by case basis but AME has to defer to FAA)

Content
Generally Safe to Fly (GO) Avoid (NO GO)
None Naloxone (Narcan) in any form (eg, injection, sublingual, spray, etc)
FlightPhysical's Staff Take Home Message
Narcan can be lifesaving, but a requirement for naloxone is a serious red flag, and external circumstances must be evaluated.
Disclaimer: Neither the FAA nor FlightPhysical.com will attempt to publish all-inclusive references. Online guidance does not replace medical advice from your PCP and/or AME. Most doctors are not AMEs, and your regular Primary Care Provider (PCP) or specialist will know more about you and/or your specific medical condition than an AME, but is probably untrained or unfamiliar with aviation medicine. Follow 14 CFR 61.53 (duty to self-ground when ill) for your safety and that of your passengers. Don't fly after taking a new medication for the first time until 48 hours have past without side effects. When in doubt - DO NOT FLY.
References
FAA AME Guide Dec 2025 version and FAA.gov