| Generally Safe to Fly (GO) | Avoid (NO GO) |
|---|---|
|
• acetaminophen (Tylenol) • aspirin (Bayer) • ibuprofen (Advil/Motrin) • naproxen (Naprosyn) • Caffeine (Commonly found in Excedrin) • lidocaine patch (Lidoderm) • muscle rub • capsaicin |
• Advil PM • Tylenol PM • Most "PM" medications contain diphenhydramine Read the label. |
Combination Cold remedies often overlap with the closely related products such as antihistamines or decongestants referenced on the Nasal Decongestants page. Consider each "active ingredient" separately and evaluate it's appropriateness for flight.
CAUTION: The FAA warns that Sudafed-like medications can speed up your heart rate; therefore, use special caution if you have an underlying heart condition. Excessive caffeine can amplify this heart rate problem and has caused more than one pilot to end up in the emergency room for a racing heart rate (including staff from FlightPhysical.com).
Disclaimer: Neither the FAA nor FlightPhysical.com will attempt to publish all-inclusive references. Online guidance does not replace medical advice from your PCP and/or AME. Most doctors are not AMEs, and your regular Primary Care Provider (PCP) or specialist will know more about you and/or your specific medical condition than an AME, but is probably untrained or unfamiliar with aviation medicine. Follow 14 CFR 61.53 (duty to self-ground when ill) for your safety and that of your passengers. Don't fly after taking a new medication for the first time until 48 hours have past without side effects.
When in doubt - DO NOT FLY.
FAA AME Guide Dec 2025 version and FAA.gov