Analgesics and Pain Medications

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FAA Aeromedical Views on Pain Medications for Pilots

Most OTC pain meds are safe to fly as long as the underlying condition that the pilot or ATC controller is acceptable. Sometimes mild pain can be a distraction, so non-sedating analgesics can actually enhance safety.

CAUTION: Occasionally OTC meds are combined with a sedating antihistamine, which can cause drowsiness. If the product you are using contains an antihistamine, it is probably not safe to fly see our antihistamine page.

Analgesics can be though of in 2 large categories. NSAIDS and Acetaminophen. Acetaminophen (paracetamol outside the U.S.) is a common over-the-counter drug used as an analgesic (pain reliever) for mild-to-moderate pain (headaches, muscle aches) and an antipyretic (fever reducer), found in many products like Tylenol. It is safe for aviators as long as the underlying condition is not limiting, but it's crucial to follow dosing to prevent serious liver damage from Tylenol especially when mixing with alcohol or other meds. Acetaminophen works by blocking pain signals in the central nervous system and reducing fever, though it lacks significant anti-inflammatory effects like NSAIDs. NSAIDs include Aspirin, Ibuprofen, Naprosyn and many similar products. This section discusses:
• Acetaminophen (Tylenol)
• Caffeine (often included in headache remedies such as Excedrin)
• NSAIDs (non-steroidal anti-inflammatory drugs) and analgesics
• Additional options for headaches
• Topical rubs
• Pain patches

While lidocaine pain relief remedies may help to temporarily block nerve signals, numbing the area for conditions like minor cuts, sunburns, insect bites, and muscle pain, available over-the-counter (OTC) in creams, patches, sprays (e.g., Salonpas, Aspercreme), or as prescription-strength options for nerve pain (shingles, neuropathy) must be used with caution. Some aviators have reported acutely appearing allergic reactions and in severe cases of adverse reaction, seizures can occur. In OTC versions these remedies can be safe and effective for pilots. They work by stopping pain signals at nerve endings, offering fast, numbing relief for skin irritations and deeper nerve pain when used as directed. Jelly and viscous solutions are more likely to cause central nervous system problems or sever allergies, but those preparations are prescription only.

CAUTION: The FAA adds a precaution about lidocaine (a topical anesthetic) creams and patches. With lidocaine application, avoid getting on hands or open wounds as this can drop blood pressure or absorb faster.

Generally Safe to Fly (GO) Avoid (NO GO)
• acetaminophen (Tylenol)
• aspirin (Bayer)
• ibuprofen (Advil/Motrin)
• naproxen (Naprosyn)
• Caffeine (Commonly found in Excedrin)
• lidocaine patch (Lidoderm)
• muscle rub
• capsaicin
• Advil PM
• Tylenol PM
• Most "PM" medications contain diphenhydramine
Read the label.

Combination Cold remedies often overlap with the closely related products such as antihistamines or decongestants referenced on the Nasal Decongestants page. Consider each "active ingredient" separately and evaluate it's appropriateness for flight.

CAUTION: The FAA warns that Sudafed-like medications can speed up your heart rate; therefore, use special caution if you have an underlying heart condition. Excessive caffeine can amplify this heart rate problem and has caused more than one pilot to end up in the emergency room for a racing heart rate (including staff from FlightPhysical.com).
Disclaimer: Neither the FAA nor FlightPhysical.com will attempt to publish all-inclusive references. Online guidance does not replace medical advice from your PCP and/or AME. Most doctors are not AMEs, and your regular Primary Care Provider (PCP) or specialist will know more about you and/or your specific medical condition than an AME, but is probably untrained or unfamiliar with aviation medicine. Follow 14 CFR 61.53 (duty to self-ground when ill) for your safety and that of your passengers. Don't fly after taking a new medication for the first time until 48 hours have past without side effects. When in doubt - DO NOT FLY.
FAA AME Guide Dec 2025 version and FAA.gov