Some vaccines will require a post-dose observation time due to either immediate or delayed side effects that will affect aeromedical safety. See below.
- FDA approved vaccines are acceptable. If vaccine is FDA approved and not
listed in the table below, contact AMCD/RFS for further guidance.
- If experiencing delayed symptoms (e.g. headache, fatigue, myalgia, or chills) 14
CFR 61.53 applies – NO fly, NO safety-related duties (SRD) until symptom-free.
Disclaimer: Neither the FAA nor FlightPhysical.com will attempt to publish all-inclusive references. Online guidance does not replace medical advice from your PCP and/or AME. Most doctors are not AMEs, and your regular Primary Care Provider (PCP) or specialist will know more about you and/or your specific medical condition than an AME, but is probably untrained or unfamiliar with aviation medicine. Follow 14 CFR 61.53 (duty to self-ground when ill) for your safety and that of your passengers. Don't fly after taking a new medication for the first time until 48 hours have past without side effects.
When in doubt - DO NOT FLY.
CODE OF FEDERAL REGULATIONS - 67.113(b)(c); 67.213 (b)(c); and 67.313(b)(c)
Sourced: FAA Dec 3, 2025