Page Contents
  • It is illegal for pilots to fly under the influence of sedating medications
  • Substance abuse and dependence requires airmen to be grounded
  1. Code of Federal Regulations for Airmen
    • First-Class Airman Medical Certificate: 67.107
    • Second-Class Airman Medical Certificate: 67.207
    • Third-Class Airman Medical Certificate: 67.307
  2. Medical History and Convictions or Administrative Actions
  3. Aeromedical Decision Considerations
  4. Protocol: See Substances of Dependence/Abuse Protocol
  5. Pharmaceutical Considerations

Sedatives and Aviation do not mix. Similar to driving, there are legal ramifications for those who attempt to fly an airplane while impaired. It is illegal to fly whether the pilot knew or should have known s/he had ingested a sedating medication.

Disclaimer: Neither the FAA nor FlightPhysical.com will attempt to publish all-inclusive references. Online guidance does not replace medical advice from your PCP and/or AME. Most doctors are not AMEs, and your regular Primary Care Provider (PCP) or specialist will know more about you and/or your specific medical condition than an AME, but is probably untrained or unfamiliar with aviation medicine. Follow 14 CFR 61.53 (duty to self-ground when ill) for your safety and that of your passengers. Don't fly after taking a new medication for the first time until 48 hours have past without side effects. When in doubt - DO NOT FLY.
FAA AME Guide Dec 2025 version and FAA.gov